Friday, August 22, 2025

The Very Late Menopause – Documented Case

 

Introduction

 

Menopause is a natural biological process that marks the end of a woman's reproductive years. While the average age of menopause in the United States is 51, some women experience menopause much later in life. In fact, it is not uncommon for women to go through menopause after the age of 60. This phenomenon, known as late menopause, can sometimes cause confusion and anxiety for women who are unsure if their symptoms are normal or indicative of an underlying health issue.


 

Causes of Late Menopause

 

There are several factors that can contribute to a woman experiencing menopause after the age of 60:

  1. Genetics: Late menopause often runs in families. If your mother or grandmother went through menopause later in life, you may also experience late menopause.
  2. Hormonal Factors: Women with higher levels of estrogen may experience menopause later in life. Additionally, some medications and hormonal therapies can delay the onset of menopause.
  3. Lifestyle: Factors such as diet, exercise, and smoking can all impact the timing of menopause. Women who maintain a healthy lifestyle may experience menopause later in life.
  4. Medical Conditions: Certain medical conditions, such as polycystic ovary syndrome (PCOS) and hypothyroidism, can cause a delay in menopause.

 

Case Report: Menstruation at Age 65

 

A peer-reviewed case report describes a 65-year-old woman presenting with vaginal bleeding, initially presumed to be post-menopausal. However, further hormonal testing revealed low LH and FSH levels—in the premenopausal range—indicating she was still menstruating naturally at age 65

  • The patient maintained regular 28-day cycles, with bleeding lasting about 5 days.
  • Family history revealed late menstruation and pregnancies in close relatives, suggesting a possible genetic predisposition

In medical literature, this is cited as the latest known case of natural menstruation continuing into the geriatric years.

 

A 65-year-old G2P2 Caucasian woman was admitted to the emergency department (ER) with a possible cerebrovascular accident. During admission, it was noted that the patient had vaginal bleeding. CT scan revealed a large fibroid, and ultrasound revealed an extremely thin endometrium, excluding endometrial pathology. Gynecology was consulted for post-menopausal bleeding, but in interviewing the patient, she was not surprised at her bleeding. Her LH and FSH levels were low, in the premenopausal range.

 

What This Means

 

  • Average age of menopause in the U.S. is around 51, with “late” defined as after age 55
  • About 5–10% of women experience it.
  • This case of menstruation at 65 with normal hormone levels is extraordinarily rare and appears unique in the literature.

 

Health Implications of Late Menopause

 

Research shows that women who reach menopause later may enjoy certain health benefits:

  • Improved vascular function, healthier lipid profiles, and less oxidative stress—suggested to be related to longer estrogen exposure.
  • Better long-term physical functioning, such as faster walking speed and lower odds of functional limitation, compared to those experiencing earlier menopause.

Possible risks accompanying prolonged estrogen exposure (as seen in late menopause) include an increased risk of breast or endometrial cancers, and potential elevated risk of thrombosis

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