Monday, March 11, 2013

Should you Take Amberen to Relieve Menopause Symptoms?

As some of you may know 3 months ago, I began taking Amberen for menopause symptoms. Within a week, the hot flashes had improved and every week, the symptoms dissipated. You are supposed to take it for 3 months and then get off of it so your normal hormones take over. I finished 2 weeks ago.

Almost immediately the night sweats began, the crankiness and insomnia returned and I realized, it was because I'm not on it anymore. I wrote to them and they said I could continue taking it, that it was fine. So I'm going to take another 3 months course of it.

I'm telling you, this stuff has helped so much! can't wait for my delivery! I hope after the next 3 months my body will stabilize. I'm grateful something helps though because menopause ain't for wimps!

From a Message Board

What is Amberen?

Amberen is a menopause relief supplement that has been both claimed to be clinically proven effective and independently tested. Amberen has also been tested on animals for efficacy. The manufacturer of Amberen, Lunada Biomedical, states that the product is an all-natural menopause supplement that contains so called smart molecules, boosting the body hormonal functions, and containing an active ingredient, Ammonium Succinate. The rest of the formulation also consists of salts and amino acids. The manufacturer of Amberen provides a full ingredient list on their site. However, the exact amount of each ingredient being used in the formulation is not provided.

The manufacturer claims that it helps the body cope with physical and emotional stress. The manufacturer also cites preliminary animal and clinical research from Russia suggesting benefit.

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How Does Amberen Work?

Your body has a mechanism that regulates hormones. With age, this mechanism wears down, causing loss of hormonal balance. Amberen rejuvenates this regulatory mechanism and alleviates common menopausal symptoms.

Amberen's Ingredients

As per manufacturer’s suggestion, a formula can only be as good as its ingredients and before any product can be called revolutionary, it must offer ingredients that that are unique, powerful, safe and unlike anything else that exists on the market. They claim that Amberen is revolutionary, due to the proprietary technology, producing perfectly shaped “smart” molecules, that female body can readily recognize and use. Inside your cells, these molecules rejuvenate mitochondria and rebalance hormone levels. The secret to our science lies in the shape of our molecules.

Lunada Biomedical is the only company in the world that has the technology to produce “smart molecules” of succinates and fumarates (key ingredients in Amberen) with specific shapes that are bio-identical to the human body, optimized for the most efficient performance.

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Ammonium Succinate

The succinate anion is derived from ammonium Succinate and, in this form, penetrates any biological membranes at the fastest rate. Once ingested, it functions as a signaling molecule and metabolic substrate. The principal signaling action involves the activation of the sympathetic function of the central and peripheral nervous systems, which results in increased sensitivity and normalized function of the hypothalamus. This activation effectively regulates the entire endocrine system. In addition, succinates contribute to the stabilization of Hypoxia Inducible Factor (HIF), which accounts for improvement of the blood flow and the, speeding-up of the synthesis of erythrocytes, is responsible for transporting oxygen, and aids in the adaptation of the metabolism to hypoxic conditions. In other words, the body better adjusts to oxygen deficiency induced by cardiovascular pathologies or during strenuous physical activities. Ammonium Succinate is an energy metabolism substrate, combined with ammonium ions, and it stabilizes mitochondrial activity in the cells. Mitochondria are the “energy stations” of each cell, especially active in the cells of the heart, liver and kidneys. An interesting point to note is that while succinates contribute to mitochondrion stimulation under the condition of energy and oxygen deficiency, they have an opposite effect in the event of mitochondrial hyperactivity. Mitochondrial hyperactivity provokes the production of active forms of oxygen and nitrogen, also known as free radicals.

In this case, Ammonium Succinate slows down mitochondrial activity and suppresses the generation of free radicals at the mitochondrial level, acting like a specific, water-soluble antioxidant. Therefore, succinates in the body possess energy-regulating, hypoxy-preventing and adaptogenic properties on both the regulatory and metabolic level, which can help the body cope with physical or psycho-emotional stress.

Calcium Disuccinate

Calcium Disuccinate is the source of easily absorbed calcium, which is vital for regulating myocardial contractility and formation of the bone tissue.

Monosodium L-Glutamate

Monosodium L-Glutamate is a salt of an amino acid, and functions as a neurotransmitter. It also regulates the chemical reactions of transamination.

It is used a safe, small amount (40mg per each dose of Amberen) of pharmaceutical-grade bioactive Monosodium L-Glutamate, which is very different from the quality and quantity of MSG used in processed foods.

Studies show that Monosodium L-Glutamate isn’t likely to cause an allergic reaction, or any other adverse side effects, unless you use extremely high doses (1,000 – 10,000 times higher than recommended). On the contrary, small dosages of Monosodium L-Glutamate, as used in Amberen, have been shown to positively affect the performance of mitochondrial-benzodiazepine receptors in peripheral tissues and stabilize energy status.


Glycine is an amino acid, involved in the processes regulating brain cell activity. In combination with magnesium, it lowers the sensitivity of glutamate receptors and makes brain mitochondrion more resistant to hypoxia, which, in turn, results in the normalization of the psycho-emotional balance in the body.

Magnesium Disuccinate Hydrate

Magnesium Disuccinate Hydrate is the source of easily absorbed magnesium, which is essential for a healthy cardiovascular system. It is also vital for the effective engaging and regulation of ATP in all energy-dependent cell reactions and for the synthesis of ferments, containing magnesium. Furthermore, it performs the functions of regulation and inhibition of the central and peripheral glutamate receptors.

Zinc Difumarate Hydrate

Zinc Difumarate Hydrate is one of the sources of zinc and fumarate, which play an important role in energy metabolism. Zinc ions are essential to the formation of ferments with active zinc centers, which are involved in important processes of synthesis occurring in the body. Sufficient amounts of zinc enhance the metabolism of beta cells in the pancreatic islets of Langerhans and promote insulin synthesis and deposition. This in turn contributes to the normalization of fat and carbohydrate metabolism and reduces the risk of diabetes.

Tocopherol Acetate

Vitamin E (in its form as Tocopherol Acetate) is a fat-soluble, natural antioxidant that prevents lipid peroxidation of cell membranes. Cell organelles and most importantly, the DNA contained in the nucleus, rely on the cell membrane to protect them. Antioxidant properties of tocopherol, supplemented by water-soluble succinate anions, promote the stabilization of membrane structure, as well as generic cell functions.

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How to Use?

Amberen is available for under $50 a bottle, and the manufacturer claims that customers will only need to take the supplement for 90 days. Then, the rejuvenated and restored hormonal system is supposed to take the job over.

Positives and Negatives

While considering Amberen as your weapon against nasty symptoms of Menopause, you may take in consideration the following Pros and Cons:


* Amberen is reported by most to be helpful with reducing menopause symptoms.
* Amberen has multiple positive testimonies from the doctors.  
* Amberen does contain all-natural ingredients, making it a safe product to consider.
* There is a 30-day risk-free trial offered. If you are not satisfied with the first 30 days of a 90-day package, you can return the unopened months of the package and receive a full refund for your purchase.
* Some customers report significant overall improvement of the sex life experiences.


* Some customers complained that it took over 90 days to see any results and that continued use of the product was needed for permanent relief.
* Does NOT contain Black Cohosh, which is seen by many professionals as a serious drawback.
* The manufacturer of Amberen claims that the product has over 30 years of clinical studies, but only specific ingredients were clinically tested over the past 30 years—Amberen as a whole product did not begin clinical studies until 2005.
* Clinical trials have not included patients with hormone-receptive cancers, so these people should be extra careful before considering using the product.

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Can Amberen reduce belly fat?

Amberen radio commercials state that Amberen targets “stubborn belly fat.” So far, there were no valid results of researches to support this statement. If Amberen really did promote fat loss from the belly, it would mean Amberen was capable of spot reduction. There is no credible proof for spot reduction.

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Amberen side effects

So far no studies have reported any negative side effects from taking Amberen.

Sources and Additional Information:

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