Gabapentin is
approved to treat seizures, but it has also been shown to help reduce hot
flashes. This drug is useful in women who can't use estrogen therapy and in
those who also have migraines.
Research
Extended-release (ER) gabapentin (Serada, Depomed), an
investigational nonhormonal drug, improved substantially sleep for menopausal
women and reduces hot flashes, according to the phase 3 clinical trial BREEZE 3,
completed in 2012.
"Right now, if women don't want to take hormones,
and if over-the-counter products, acupuncture, and lifestyle changes do not
work, we don't have any FDA [US Food and Drug Administration] approved
therapies," said lead researcher JoAnn Pinkerton, MD, who is professor of
obstetrics and gynecology at the University of Virginia in Charlottesville and
past president of NAMS.
A New Drug Application was submitted for gabapentin ER in
July 2012. If approved, the drug will be the first nonhormonal, non-antidepressant
treatment for the bothersome symptoms of menopause, Dr. Pinkerton explained.
In the older study of 2005, completed by the University
of Rochester Cancer Center, involved 420 women with breast cancer who been
suffering from hot flashes. The women were divided into two different groups.
One group was given 300 mg of the medication per day while the other group was
given 900 mg of gabapentin.
The subjects were asked to record the frequency and
intensity of their hot flashes before the study and during weeks four and
eight. The results of the study showed that 900 mg of gabapentin is effective
for controlling hot flashes. The subjects who only took 300 mg of the
medication did not notice a significant decrease in their hot flashes. The
researchers concluded by saying that gabapentin should be used to treat hot flashes.
Gabapentin is FDA-approved currently for seizures and
postherpetic neuralgia (shingles). The drug also has been used off label to
treat diabetic neuropathy, chronic pain, and restless leg syndrome. However,
the drug has not been officially approved by FDA for treatment of the
menopausal symptoms as hot flashes and insomnia after the drug developer,
Depomed, application has been reviewed in 2013.
Still, many women consider the drug as effective, though
the extend of the possible effects may vary.
Before you take
Gabapentin
Tell your doctor if you are taking other medications
including:
* Treatment for stomach or duodenal ulcers such as
cimetidine
* Antacids or other medications to treat heart burn or
reflux
Consumption and
Dosage
Swallow whole with a full glass of water. It does not
matter if you take Gabapentin before or after food. Initially take 300mg at
night, increase the dose by 300mg every two to three days (add morning dose
then midday dose if no side effects) until taking 300mg three times a day. It
is advisable to take Gabapentin at the same time each day. If you miss a dose
take it as soon as you remember, however if it is almost time for your next
dose, take only your usual dose at that time.
Side Effects
side effects of gabapentin are somnolence, drowsiness,
dizziness, and a "spacey" feeling. These effects tend to subside
after a month of treatment. Gabapentin has a half-life of 5 to 7 hours, which
means that a single dose taken prior to bedtime will have an effect throughout
the night.
People are less likely to experience side effects if they
take it at bedtime or with a meal. They are also less likely to experience side
effects if the dosage is gradually increased.
Like many other anti-seizure medications, Gabapentin may
increase the risk of suicide. That is why people who take these medications
should be watched closely for signs of suicidal behavior. Women who are worried
about this possible side effect should make sure that they discuss it with
their doctor.
Is Gabapentin
Addictive?
Many women who take Neurontin for hot flashes are
concerned about whether the drug is addictive. The good news is that Neurontin
is not considered an addictive drug. However, it is important to note that it
is possible for one to develop a physical dependence on the drug. Some people
may experience withdrawal symptoms for up to 45 days after they stop taking the
drug. Insomnia, anxiety, pain, sweating and nausea are some of the most common
withdrawal symptoms.
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